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A Practical Guide to Titrations in Quality Testing

This module looks at the basics of potentiometric and Karl Fischer titrations. It provide an overview of the components of an autotitrator and different titration methods.

  • Introduction to titrations and basic components of titrations including pipette, burette, and a titrant

  • Detection of reaction completion by end point analysis

  • Types of titrations including voltametry, potentiometry, amperometry, photometry etc.

  • Autotitrator and its use in performing potentiometric titrations

  • Components of autotitrator including aqueous and non aqueous electrodes, anti diffusion valves, electrolytes etc.

  • Types of Karl Fisher titrations including volumetric and coulometric

  • Standardization, calibration, and end point detection

  • Factors impacting titrations as well as precautions that must be taken

Why it matters

Titration is used to measure the concentration of a test sample by adding a known quantity of another substance to the sample. Determination solution concentration is widely used in drug development and manufacturing. Performing proper titrations\, and knowledge of titration equipment is crucial for analysts.

Who is it for

This course is ideal for quality control and quality assurance team members who conduct and evaluate test results prior to batch releases

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