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A Practical Guide to Sample Preparation Techniques - Part 1

Part 1 of this two-part module covers the basics of sample preparation focusing on weighing, crushing and grinding, sonication, shaking, dilutions and glassware handling

  • Types of weighing balances, steps to weighing and typical precautions

  • Grinding tools such as porcelain, agate, stainless steel or automated grinder

  • Parameters when selecting mortar and pestle

  • Sonication and different types of sonicators including probe type and ultrasonic bath.

  • Steps to sonication and shaking

  • Introduction to dilution and volumetric flasks

  • Glassware handling including selection of glassware

  • Maintenance and cleaning of glassware as per USP

  • Proper handling of glassware with typical do’s and don’ts

Why it matters

Proper sample preparation is critical to ensure that evaluation of batch quality is accurately performed\, and to ensure reproducible results. Grinding and crushing\, followed by weighing\, are the oldest ways of preparing samples for a composite assay of pharmaceutical tablets. Similarly\, sonication can be used for degassing\, particle size reduction and agitation. Knowledge of these techniques\, and their various applications is crucial for quality personnel in pharmaceutical enterprises.

Who is it for

This module is for employees in production quality control and quality assurance who prepare samples for in-process or final testing.

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