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Particle Size Analysis and its Applications

Particle Size Analysis and its Applications

This eLearning module explores the principles of particle size analysis, especially using the Malvern instrument. It will also provide an overview of components and operation of the analyzer.​


  • Introduction to particles and particle sizes​

  • Impact of particle size and importance of particle size analysis​

  • Principle of sieve and laser diffraction for particle size analysis​

  • Optical theories such as fraunhofer and mei scattering, used to calculate the light intensity distribution patterns produced by particles ​

  • A typical particle size distribution​

  • Components of a Malvern instrument including light source, dry and wet accessories etc.​

  • Sample preparation​

  • Usage of surfactants and dispersing aids​

  • Operation of the instrument​

  • Data analysis of different distribution types​

  • Do’s and don’t while handling the instrument​

  • Why it matters

    Pharmaceutical raw materials are processed through grinding, sieving, micronizing and blending operations. Each of these operations affect particle size which is critical to final drug product quality. Finer particles dissolve quicker, and the speed of dissolution has a direct effect on bioavailability and effectiveness of a drug. Understanding the theory and applications of particle size determination is crucial for analysts.​

  • Who is it for​ ​

    This module is relevant to quality control and quality assurance team members who conduct and evaluate particle size data​

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